Monthly Archives: September 2017

What is Breast Cancer?

To answer the question “What is breast cancer?”, we have to start with the fundamentals, the smallest parts our bodies are made up with: the human cells.

When we talk about aging, getting sick and getting disease, usually we don’t realize that we don’t, but actually our cells do. The health of our body depends on how healthy our cells are. The human body is made up of about 80 trillion cells.
Those cells continually replicate themselves.
Consequently, to slow down our aging process and limit our change of getting sick we have to protect and feed our cells properly.

Our cells are made up of atoms. If these cells are healthy, they consist of paired electrons. Healthy cells replicate and keep our body young and disease free. But if atoms are missing electrons, they destroy surrounding atoms by “stealing” their electrons. Atoms that are missing an electron are called “free radicals”. Free radicals alter or  destroy cells and
are the cause of premature aging, sickness and disease, like cancer, heart disease, stroke, osteoporosis and many others.

Every day, the DNA in each cell in your body faces about 10,000 attacks from
cell-damaging free radicals.
Free radicals are naturally produced as your body turns fuel to energy, but you also get them from pollution in air and water, stress, smoking and radiation from the sun.

These volatile molecules cruise around your body trying to stabilize themselves
by stealing electrons from other molecules. When they succeed, they create
still more free radicals, causing a sort of snowballing procession of damage.

Free radicals don’t just occasionally pop up here and there. Up to 5% of the
oxygen that each cell uses is converted into free radicals.

Free radical damage is thought to play a role in the accumulation of low-density
lipoprotein (LDL) cholesterol and the lining of your artery walls.
This can lead to a narrowing of the arteries called atherosclerosis, which
contributes to heart disease. And when free radicals damage DNA inside the cells,
it can replicate a damaged cell.The results can be cell mutations that lead to cancer.

Pollution in our environment, pesticides and insecticides used on our land, water treated with chlorine and smoking are sources of free radicals.

So what’s the solution? Fortunately, there are antioxidants who have extra electrons to give away to free radicals, which eliminates their harmful effect and are our body’s defense against the harmful effect of free radicals, causing aging, sickness and disease like cancer.

Cabbage contains an abundance of vitamins, C, E, and carotene and two compounds that studies show can help prevent cancer.
Researchers reviewed almost 100 studies that evaluated the relationship between cruciferous vegetables, such as cabbage and cancer. They found that in 70% of the studies, cabbage consumption was associated with a lower risk of cancer. Cabbage is particularly effective in preventing breast-, lung-, and prostate cancer.

However, only 2% of these vitamins are present in the average American diet.
Most Americans today don’t eat their cabbage or any other vegetable.The average intake is less than one serving per day of either fruit or vegetables.

The first of these compounds, indole-3-carbinol, or I3C, is especially effective against
breast cancer. The compound acts as an antiestrogen, which means that it sweeps up harmful estrogens that have been linked to breast cancer.

Most breast cancer is linked to deficit in estrogen metabolism.
The under-nourished female body can’t deactivate its estrogen properly. It uses what is called the estradiol 16-alpha hydroxylation pathway, which leaves the hormone still active enough to cause cell transformation in the breast (and reproductive organs).
Over years these cells gradually transform to cancer.The properly nourished female body, however, uses what is called the estradiol 2-alpha hydroxilation pathway, which neutralizes the hormone completely and never leads to breast cancer.

The other compound found in cabbage, called sulforaphane, has been shown to inhibit carcionogens and aid in DNA repair.

Women in Poland eat three times as much cabbage,especially raw cabbage,
as women in the US.
Researchers studied hundreds of Polish women living in the US and found that women who ate four or more servings of cabbage per week while preteens were 72% less likely to develop breast cancer as adults than the women who ate one serving or less of cabbage a week while preteens. Eating lots of cabbage as adults also provided significant cancer protection.

Dr. Donald Malins, a biochemist from Seatle, reported a new method fot identifying structural changes in the DNA of breast tissues. By using an instrument that bounces  infrared radiation off the DNA and by analyzing the signals via a sophisticated computer, he was able to follow the structual damage to the DNA caused by free radicals.

Researchers agree with Malins that the development of cancer is a multistage process that usually takes decades to develop. In adults, cancer may take twenty or even thirty years to develop from the initial mutation of the DNA to its full-blown manifestation. In children, this process may develop more quickly because of their more rapid cell turnover.


Malins noted significant changes within the structure of the DNA as he followed it from normal breast tissue to metastatic breast cancer in all its developmental stages.

Dr Malin believed oxidative stress was the cause of this predictable damage to
the DNA, which eventually led to the formation of breast cancer.
He further argued that cancer was not so much the result of disfunctional genes as it was the result of genetic damage that highly reactive free radicals caused.

For the past forty years, researchers have believed that abnormal genes are the driving force behind all cancers. But now researchers are beginning to believe instead that individuals with certain genes are simply more vulnerable to oxidative stress than others. This may explain the familial patterns of many types of cancer.

Nutritional science offers us the greatest hope in our fight against cancer and
several other degenerative diseases.
They not only help to prevent cancer but may actually enhance the traditional chemo- and radiation therapy.
How can the process of building up the body’s natural defence be bad?
Shouldn’t physicians want their patients to be as healthy as possible,since cancer treatments are going to put patients under the greatest stress they have had to endure in their lives?

Natural antioxidants and their supporting nutrients are the ideal chemo-preventive agents for many reasons.

* They limit and even prevent the free-radical damage to the DNA nucleus of
the cell.
* They provide the proper nutrients needed for the body to repear any damage that has been done already.
* They are save and may be taken over a lifetime. (Pharmaceutical drugs do not share this advantage. Tamoxifen, which has been shown to decrease the risk
of breast cancer, has very serious side effects.)
* They are relatively inexpensive.
* They provide the best defense against further advancement of cancer.
* They protect the body against oxidative stress that chemotherapy and radiation create.
* They support the cancer-fighting ability of chemotherapy and radiation.
* They inhibit the replication and growth of the cancer.
* They have been shown to cause tumor regression in some cases.

We can’t deny that the effectiveness of traditional cancer treatments has reached a plateau. Oncologists and radiation therapists must become more open-minded about antioxidant use in their patients. As researchers seriously consider the use of multiple antioxidants at optimal levels, cancer prevention and treatment may well be revolutionized. In the meantime, the research that is presently available supports the use of antioxidants in all stages of chemo- prevention and cancer therapy.

The CSIRO has given practical guidelines to minimize free-radical damage.
You can read them in my article: How to protect against cancer.

Phytochemicals, compounds to cut cancer and heart risks

INDOLES
Phytochemicals have an important function to prevent some cancers and heart disease .
One of them are called Indoles. You find them in crusiferous vegetables like cabbage, broccoli, cauliflower and mustard greens. They have a bitter taste that bugs don’t like.
The phytochemical responsible for this way of plant protection is called Indole-3-
carbinol, known by researchers by the nickname I3C.
In humans, this compound plays a role in regulating hormones, which may be useful
in preventing breast cancer.

Researchers at the Strang Cancer Prevention Center in New York City found that when
women took 400 milligrams of I3C a day, about the amount found in half a head of
cabbage, their levels of the harmless estrogen increased significantly.
In fact, they had the same levels as those found in marathon runners, which is quite a
feat, since vigorous exercise has been shown to have a strong positive effect on
estrogen levels. I3C also helps stop tumor cells from spreading to other parts of the body,
Studies also show that I3C may slow the growth and reproduction of prostate-cancer cells.
That’s why you should say yes to broccoli and cabbage.

ORGANOSULFUR COMPOUNDS
Other phytochemicals are organosulfur compounds, called allylic sulfides.
They are one of nature’s most potent compounds to decrease your risks of cancer and heart disease. They also raise good HDL cholesterol and stimulate enzymes that suppress tumors.
You will find them in onions, garlic, also but in lower concentration in leeks and chives.

Allylic sulfides also have the unique potency to keep cholesterol and other blood fats known as triglycerides from causing health-threatening blood clots and hardening of the arteries.
Allicin, which researchers believe to be the most potent compount in garlic, and diallyl
disulphyde also made blood vessels relax, reducing blood pressure and improving bloodflow.
Allicin also has potent germ killing powers. Studies show that it can kill microbes responsible for colds, the flu, tummy viruses, yeast infections, and possibly even tuberculosis.

Other studies have shown that taking two or more servings of garlic per week can help
protect against colon cancer. It can also stop the growth of cancer cells, once they develop.

PHYNOLIC COMPOUNDS
This is another phytochemical, also called polyphenols.You will find them in most fruits,
vegetables, cereal grains, and green and black teas. These compounds fight cancer on two
fronts. They stimulate protective enzymes while squelching harmful ones, and they’re also
havy-duty antioxidants.
Most active polyphenols include ellagic acid from strawberries, green tea polyphenols,
and curcumin, the yellow collering in turmeric.
Curcumin plays a role in cancer prevention because it act as an antioxidant.
It also seems to inhibit the growth of cancer cells and prevent or help to treat Alzheimer’s
disease and arthritis.

SAPONINS
One of the most common phytochemicals are the saponins. You will find them in a wide
variety of vegetables, herbs and legumes, like spinach, tomatoes, potatoes, nuts, and oats.
Soy beans alone contain 12 different types of saponins.

Studies show that people who eat saponin-rich diets have consistently lower rates of breast- prostate- and colon cancer,
Unlike other cancer-fighting phytochemicals, however, saponins possess a unique array
of weapons. One way that they help prevent cancer is by binding with bile acids, which
over time may metabolize into cancer-causing compounds, and eliminating them from the
body, says Dr Rao, professor of nutrition at the University of Toronto.

They also stimulate the immune system so that’s better able to detect and destroy precancerous cells before they develop into full-blown cancer.

But perhaps the most important ability of saponins is to target the cholesterol found in cancer cell membranes. Cancer cells have a lot of cholesterol in their membranes, and saponins selectively binds to these cells and destroy them.

Not surprisingly , this ability to bind to cholesterol is helpful for lowering total cholesterol
as well. Saponins bind with bile acids, used for digestion in the intestinal tract.
The bile is then excreted, instead of being reabsorbed. Since bile acids are made of cholesterol, getting rid of some of these acids means that your body has to use up cholesterol to make more, effectively lowering cholesterol levels in the process.
See also my article titled: Phytonutrients, compounds from the garden for good health.

 

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Flavonoids

Flavonoids are powerful antioxidants, and sturdy defenders against heart disease and cancer. See also my article titled: Antioxidants in green leafy vegetables
Like carotenoids, flavonoids add color – specifically red, yellow, blue and shades of brown
to the foods we eat and drink.
Present mostly in apples, celery, cocoa, (dark chocolate), cranberries, grapes, broccoli, endive, onions, green and black teas, and red wines.

But experts are beginning to discover that these compounds are doing more.
Some flavonoids make the linings of blood vessels more supple, lowering blood pressure and protecting against a buildup of heart- threatening plague. In one study, grape juice and
chocolate had this effect. Flavovoids also act like Teflon coating for the millions of tiny disks in your blood called platelets. They keep the platelets from clumbing together in the bloodstream and forming clots, which helps prevent heart attacks and stroke.

A recent study at the Harvard Medical School lab has found that one magical flavonoid found in wine and grapes: resveratrol, also lowers blood sugar levels and boosts liver function. In fact, in a group of lucky mice, it increased longevity by 31%.
In one study at the university of Virginia, resveratrol – found in grape skins, raspberries,
mulberries, and peanuts – literally starved cancer cells by interfering with a protein called
nuclear factor-kappa B, that helps food them.

In one Dutch study that examined the eating habits of 800 men, aged between 65 and 84,
researchers found that those who got the least flavonoids in their diets, were 32% more
likely to die from heart attacks than those who ate the most. It didn’t take many flavonoids
to get the benefits. The high-flavonoid group had the equivalent of 4 cops of black tea,
a half cup of apple, and 1//8 cup of onions per day.

When it comes to cancer prevention, flavonoids may help out by influencing cel-signaling
pathways – the way cells turn genes on and off in order to perform thousands of everyday
maintenance activities. Flavonoids may help turn on genes that stop cancer cells from
dividing or invading healthy tissues, or even help activate genes that make cancer cells
commit suicide, say experts from the Linus Pauling Research Institute at Oregon State
University in Corvallis.

In a recent study at the University of California, Los Angeles, those prostate-cancer
survivors who drank 8 ounces of pomegranate juice daily, increased by nearly 4 times
the period during which their PSA levels (prostate specific antigens) a cancer biomaker,
stayed constant. The study even surprised the researchers, who say that the combination
of flavonoids, anti-inflammatory compounds, and antioxidants in pomegranate juice
may be responsible.

Antioxidants in Green Leafy Vegetables

Antioxidants you find in the red of tomatoes and the yellow plant pigments in carrots  are called carotenoids. You also find them in green leafy vegetables They belong to the family of phytonutrients. See also my article: Phytonutrients, compounds from the garden.
These carotenoids are powerful antioxidants to fight against heart disease and certain forms of cancer.

Research has shown promising results from a number of carotenoids, particularly lycopene
(also found in tomatoes), lutein (found in vegetables such as spinach and kale), and
zeaxanthin ( found in dark green leafy vegetables). All three play a powerful role as antioxidants  in cancer prevention.

Researchers in the Tufts University Carotenoids Health Laboratory say: “Skipping fruits &
vegetables is part of the classic “profile” of people who develop cancers of the head and
neck, but that increasing your intake of these antioxidants rich products may cut your risk for recurrence of these cancers.

In one study, researchers found that people in northern Italy who ate seven or more
servings  of raw tomatoes every week  had a 60% lower change of developing colon, rectal,
and stomach cancer than those who only ate two servings or less.

German researchers have found that cooked tomato products containing some oil –
such as spaghetti sauce – boost lycopene absorption dramatically. They believe that
heating  and crushing releases more lycopene, and that the body  needs substances in
oil to  help better absorption.

Harvard researchers, looking at green leafy vegetables, especially spinach, had quite
an eye-opener. They found that people eating the most lutein and zeaxanthin – which
are two carotenoids , powerful antioxidants found in these vegetables – had a 43% lower risk of macular degeneration  than those eating the least.
Macular degeneration is the leading cause of irreversible vision loss in people  over 50.
Lutein and zeaxanthin concentrate in your retinas and protect them by absorbing
harmful blue-wavelength light found in sunshine.

Other members of the Phytonutrients are: flavonoids, indoles,  lignans, monoterpenes, saponins, organosulfur – and phenolic compounds, which are all powerful antioxidants,
I will discuss in future articles.  If you like to know more about plant-based nutrition,
I refer to : Nutrition studies.org